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Creatine Kinase Is Associated With Recurrent Stroke and Functional Outcomes of Ischemic Stroke or Transient Ischemic

Shiyu Li1,2, Anxin Wang1,2, Yijun Zhang1,2

  • 1Department of Neurology Beijing Tiantan HospitalCapital Medical University Beijing China.

Journal of the American Heart Association
|March 4, 2022
PubMed

Insights

Elevated serum creatine kinase (CK) in patients with acute ischemic stroke or transient ischemic attack is linked to increased risks of stroke recurrence, death, and disability. These associations were significant at 3 months and 1 year, with sex influencing outcomes.

Area of Science:

  • Neurology
  • Cardiology
  • Biochemistry

Background:

  • Elevated serum creatine kinase (CK) is frequently observed in post-stroke patients.
  • Understanding the prognostic value of CK in acute ischemic stroke is crucial for patient management.

Purpose of the Study:

  • To investigate the association between serum CK levels and clinical outcomes in patients with acute ischemic stroke or transient ischemic attack.
  • To determine if CK levels can predict stroke recurrence, death, and disability.

Main Methods:

  • Analysis of 8910 patients from the Third China National Stroke Registry (CNSR-III).
  • Measurement of baseline serum CK levels post-admission.
  • Statistical analysis of associations between CK levels and outcomes (stroke recurrence, death, disability at 3 months and 1 year).

Main Results:

  • Elevated CK levels were significantly associated with higher risks of recurrent stroke (HR 1.53), death (HR 1.68), and disability (OR 1.57) at 3 months, persisting at 1 year.
  • These associations remained significant after adjusting for confounding factors.
  • The impact of CK on death and disability was more pronounced in male patients compared to females (P<0.05 for interaction).
  • Elevated CK-MB levels did not show a significant association with clinical outcomes.

Conclusions:

  • Elevated serum CK is a significant predictor of recurrent stroke, mortality, and disability in patients with acute ischemic stroke or transient ischemic attack.
  • Serum CK serves as a valuable prognostic marker for poor functional outcomes.
  • Sex is a modifying factor in the relationship between elevated CK and adverse clinical outcomes.

Keywords:
creatine kinasedisabilityischemic strokerecurrence

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