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Updated: Oct 1, 2025
Use of Electromagnetic Navigational Transthoracic Needle Aspiration E-TTNA for Sampling of Lung Nodules
Published on: May 23, 2015
Comparison between computed tomography-guided core and fine needle lung biopsy: A meta-analysis
Yong Li1, Fang Yang1, Ya-Yong Huang2
1Sichuan Key Laboratory of Medical Imaging and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Computed tomography (CT)-guided core needle biopsy (CNB) offers superior sample adequacy compared to fine-needle aspiration biopsy (FNAB) for lung nodules. However, both biopsy methods show similar diagnostic accuracy and safety profiles.
Area of Science:
- Pulmonology
- Radiology
- Oncology
Background:
- Lung nodules and masses require accurate diagnosis.
- Biopsy is crucial for evaluating lung lesions.
- Comparing different biopsy techniques is essential for patient care.
Purpose of the Study:
- To compare the safety and diagnostic performance of CT-guided core needle biopsy (CNB) versus fine-needle aspiration biopsy (FNAB).
- To evaluate the effectiveness of these two biopsy methods for lung nodules/masses.
Main Methods:
- A meta-analysis of relevant studies from PubMed, Embase, and Cochrane Library databases.
- Studies published up to June 2020 were included.
- Data analysis was performed using RevMan 5.3.
Main Results:
- Nine studies involving 2175 procedures (819 CNB, 1356 FNAB) were analyzed.
- CNB demonstrated significantly higher sample adequacy rates (95.7%) than FNAB (85.8%).
- Diagnostic accuracy and rates of pneumothorax, hemorrhage, and chest tube insertion were similar between CNB and FNAB.
Conclusions:
- CT-guided CNB provides better sample adequacy for lung biopsies than FNAB.
- CNB does not offer superior diagnostic accuracy or safety compared to FNAB for lung nodules.
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