Multifunctional fluorescent probe for effective visualization, inhibition, and detoxification of β-amyloid
Ziqi Zhang1, Yue Cao1, Qiong Yuan1
1Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, P. R. China. duanxr@snnu.edu.cn.
Abstract:
A multifunctional reactive fluorescent probe DTB was constructed for biosensing, aggregation inhibition, and toxicity alleviation of β-amyloid. The synergistic effect of hydrophobic interaction and covalent interaction makes DTB have more stable binding and better selectivity to Aβ. The detoxification effect of DTB on Aβ aggregates was also verified in live nerve cells and microglia cells. Furthermore, DTB exhibits an excellent staining of Aβ plaques.
