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Updated: Oct 1, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Association between periodontitis and chronic kidney disease
Karo Parsegian1, David Randall2, Mike Curtis3
1Department of Surgical Dentistry, Division of Periodontics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Periodontology 2000
|March 4, 2022
Summary
Periodontitis, an oral condition, is linked to chronic kidney disease (CKD). Research explores their connection, shared risks, and potential benefits of dental care for kidney health, emphasizing interprofessional collaboration.
Area of Science:
- Oral Health and Nephrology
- Chronic Disease Epidemiology
Background:
- Periodontitis and chronic kidney disease (CKD) are prevalent global health issues.
- Patients with CKD often exhibit a high prevalence of periodontitis, with shared risk factors contributing to both conditions.
- The precise bidirectional relationship and causal links between periodontitis and CKD remain under investigation.
Purpose of the Study:
- To review current literature on the association between periodontitis and CKD.
- To investigate potential underlying mechanisms connecting these two diseases.
- To determine if an independent association exists and if periodontal interventions impact CKD risk.
Main Methods:
- Comprehensive literature review of studies examining periodontitis and CKD.
- Exploration of biological and epidemiological pathways linking oral health and kidney function.
- Assessment of evidence for periodontal treatment influencing CKD development and progression.
Main Results:
- Shared risk factors contribute to the prevalence and severity of both periodontitis and CKD.
- Evidence suggests a potential link, though the exact causal relationship requires further elucidation.
- Improved oral hygiene and periodontal treatment may reduce the risk of developing CKD, warranting specific management protocols.
Conclusions:
- The interprofessional collaboration between dental and nephrology teams is crucial for managing patients with CKD.
- Oral health assessment should be integrated into the comprehensive care of individuals with chronic kidney disease.
- Further research is needed to fully define the relationship and optimize interventions for this patient population.
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