Related Experiment Video
Updated: Oct 1, 2025

Whole-Mount Immunofluorescence Staining, Confocal Imaging and 3D Reconstruction of the Sinoatrial and Atrioventricular Node in the Mouse
Published on: December 22, 2020
Where the heart beats
1University of Strasbourg/CNRS, UMR7177 Chemistry Institute, Membrane Biophysics and NMR, Strasbourg, France; Institut Universitaire de France, 75005 Paris, France.
Abstract:
In this issue of Structure, Reddy et al. present details about the structure, topology, and dynamics of the small membrane protein DWORF, a regulin that activates the Ca2+ pump SERCA. State-of-the art oriented solid-state NMR spectroscopy in combination with molecular dynamics simulations reveal the structure of this cardiac muscle protein.
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