Related Experiment Videos
Augmentin compared with oxytetracycline for chest infections in general practice
British Journal of Diseases of the Chest
|April 1, 1986
Summary
Augmentin demonstrated superior efficacy over oxytetracycline in treating chest infections, leading to better overall patient response and faster symptom resolution. Both antibiotics were well-tolerated with minimal adverse events.
Area of Science:
- Infectious Diseases
- Pharmacology
- General Practice
Background:
- Chest infections are common in general practice.
- Antibiotic selection is crucial for effective treatment.
- Oxytetracycline has been a traditional choice for respiratory infections.
Purpose of the Study:
- To compare the efficacy and tolerability of Augmentin versus oxytetracycline for chest infections.
- To evaluate the overall treatment response and resolution of specific symptoms.
- To assess the safety profile of both antibiotics in a general practice setting.
Main Methods:
- Investigator-blind, randomized controlled trial.
- 748 patients with chest infections were allocated to 7-day treatment.
- Treatment groups received either Augmentin or oxytetracycline.
Main Results:
- Augmentin showed significantly better overall treatment response at day 7 (P<0.001) and day 14 (P<0.01).
- Augmentin was more effective in resolving chest pain (day 7, P<0.025) and cough (day 14, P<0.005).
- Sputum purulence clearance was significantly better with Augmentin by day 14 (P<0.001).
Conclusions:
- Augmentin is a superior and well-tolerated treatment for chest infections compared to oxytetracycline.
- Augmentin offers faster resolution of key clinical symptoms.
- The study supports Augmentin as a preferred option for managing respiratory tract infections.