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Updated: Oct 1, 2025

In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
Decreased Risk of Strokes in Children with Ventricular Assist Devices Within ACTION
David M Peng1, Muhammad F Shezad2, Angela Lorts2
1University of Michigan Congenital Heart Center, CS Mott Children's Hospital, Ann Arbor, MI, USA. davepeng@med.umich.edu.
Abstract:
We sought to characterize strokes in children with ventricular assist devices. Of 407 patients in the ACTION registry (4/1/18-5/3/2021), 45 (11%) experienced 52 strokes (45 ischemic and 7 hemorrhagic). Median time to stroke was 23.5 days and 19/52 (37%) occurred ≤ 10 days. Stroke rate was 0.09 and 0.63 strokes per patient-year for implantable continuous and paracorporeal devices, respectively. Patients with stroke were younger, more likely to have congenital heart disease and have been on extracorporeal membrane oxygenation at time of VAD. Based on these data, ACTION is now focused on decreasing strokes in these higher-risk patients with particular attention to the peri-implant period.
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