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Advanced drug delivery system against ischemic stroke.
Shanshan Zhang1, Yuan Zhou1, Ruoqi Li1
1School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Summary
Drug delivery systems using nanocarriers offer new hope for ischemic stroke treatment by targeting the brain and enhancing neuroprotection. These advanced systems overcome limitations of current therapies like recombinant tissue plasminogen activator (tPA).
Area of Science:
- Neuroscience
- Biomedical Engineering
- Pharmacology
Background:
- Ischemic stroke is a leading cause of death and disability, with limited treatment options.
- Current treatments like recombinant tissue plasminogen activator (tPA) have narrow therapeutic windows and risks.
- The blood-brain barrier (BBB) hinders effective drug delivery for neuroprotection.
Purpose of the Study:
- To review nanocarrier-based strategies for improving drug delivery in ischemic stroke.
- To discuss targeted and stimuli-responsive nanocarriers for brain and thrombus delivery.
- To explore precise treatment approaches for ischemic stroke.
Main Methods:
- Review of nanocarrier strategies for thrombus targeting.
- Analysis of nanocarriers enhancing neuroprotective agent accumulation in the brain.
- Discussion of stimuli-responsive nanocarriers for ischemic stroke treatment.
Main Results:
- Nanocarriers can protect drugs from elimination and target specific sites like thrombi and the central nervous system (CNS).
- Stimuli-responsive nanocarriers enable targeted drug release in response to internal or external cues.
- These systems show potential to increase therapeutic efficacy and overcome BBB challenges.
Conclusions:
- Nanocarrier-based drug delivery systems offer promising solutions for ischemic stroke therapy.
- Targeted and stimuli-responsive nanocarriers can enhance drug delivery to the brain and ischemic regions.
- Further development of these systems could lead to more precise and effective ischemic stroke treatments.