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Related Experiment Videos

Control of human colonic motor function.

J D Huizinga, E E Daniel

    Digestive Diseases and Sciences
    |August 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Human colonic motility involves complex neural and myogenic controls, but structural evidence is lacking. Further research is needed to reconcile in vitro and in vivo findings and reexamine conventional beliefs about colon function.

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    Area of Science:

    • Gastroenterology
    • Physiology
    • Neuroscience

    Background:

    • Human colonic motility is regulated by smooth muscle electrical activity, intrinsic and extrinsic nervous systems, and hormones.
    • The structural underpinnings of neural and myogenic control in the colon remain undemonstrated.
    • Gap junctions are absent between colonic muscle cells, and nerves are not in close proximity to smooth muscle cells.

    Purpose of the Study:

    • To describe and compare in vitro myogenic control with in vivo techniques.
    • To critically evaluate in vitro and in vivo measurements of colonic motility.
    • To attempt a reconciliation between disparate findings and interpretations.

    Main Methods:

    • In vitro studies of myogenic control.
    • In vivo techniques for assessing colonic motility.

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  • Critical evaluation and comparison of in vitro and in vivo data.

    • Main Results:

    • Myogenic control observed in vitro is described and compared with in vivo results.
    • In vitro and in vivo measurements were critically evaluated.
    • No suitable animal model exists to resolve conflicting findings.

    Conclusions:

    • Neural control likely modulates myogenic activity and acts directly on the colon.
    • Integration of nerve activities occurs in the colon, prevertebral ganglia, and spinal cord (in animals).
    • Further studies are needed to link transit and motility, and reevaluate existing beliefs.