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Related Experiment Video

Updated: Oct 1, 2025

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays
08:37

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays

Published on: April 18, 2025

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CD38: A Significant Regulator of Macrophage Function.

Wentao Li1,2, Yanling Li3, Xi Jin1,2

  • 1NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Frontiers in Oncology
|March 7, 2022
PubMed
Summary
This summary is machine-generated.

Cluster of differentiation 38 (CD38), an enzyme and cell receptor, impacts macrophage function, proliferation, and polarization. Targeting CD38 may offer new therapeutic strategies for macrophage-related diseases.

Keywords:
CD38SASP (senescence-associated secretory phenotype)calciummacrophagesmechanism

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Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Cluster of differentiation 38 (CD38) is a cell surface glycoprotein with NADase activity.
  • CD38 influences immune cell activation, proliferation, and macrophage aggregation/polarization.
  • Previous research indicates CD38's significant role in regulating macrophage function.

Purpose of the Study:

  • To review the multifaceted roles of CD38 in macrophage biology.
  • To explore CD38's mechanisms in macrophage proliferation, polarization, and function.
  • To examine CD38's potential as a biomarker and therapeutic target in macrophage-related diseases.

Main Methods:

  • Literature review of studies on CD38 and macrophages.
  • Analysis of CD38's enzymatic and receptor functions.
  • Investigation of CD38's impact on macrophage NAD+ levels and infection susceptibility.

Main Results:

  • CD38 knockout affects macrophage aggregation and polarization.
  • Liver X receptor-alpha (LXR) agonists reduce macrophage infection via CD38-dependent NAD+ depletion.
  • CD38 is implicated in regulating macrophage function.

Conclusions:

  • CD38 plays a critical role in macrophage proliferation, polarization, and function.
  • Understanding CD38's mechanisms provides a basis for targeting it in diseases.
  • CD38 shows promise as a biomarker and therapeutic target for macrophage-related conditions.