Advances in Endoscopic Photoacoustic Imaging

Area of Science:

• Biomedical Imaging
• Optical Imaging
• Medical Technology

Background:

• Photoacoustic (PA) imaging offers high molecular contrast and ultrasound (US) imaging depth.
• Conventional microscopic PA imaging struggles with light scattering and attenuation in deep tissues.
• Endoscopic PA technology delivers excitation light directly into body cavities for enhanced imaging.

Purpose of the Study:

• To review representative endoscopic PA probe configurations.
• To discuss preclinical applications of endoscopic PA imaging.
• To explore challenges and future directions in the field.

Main Methods:

• Review of existing literature on endoscopic PA probe designs.
• Analysis of preclinical studies utilizing various endoscopic PA probes.
• Discussion of technological challenges and potential advancements.

Main Results:

• Various endoscopic PA probes have been developed for specific applications.
• Successful preclinical applications include intravascular imaging of atherosclerotic plaque and endoscopic imaging of colon cancer.
• The review highlights the potential of endoscopic PA for functional and molecular imaging.

Conclusions:

• Endoscopic PA imaging provides a viable solution for deep tissue visualization.
• Further development is needed to address current challenges and expand clinical applications.
• The technology holds significant promise for early disease detection and monitoring.