IgA vasculitis following COVID-19 vaccination
Naoya Nishimura1, Yasuko Shiomichi2, Satoshi Takeuchi2
1Department of Rheumatology, Hamanomachi Hospital, Fukuoka, Japan.
Modern Rheumatology Case Reports
|March 7, 2022
Summary
Two cases of IgA vasculitis occurred after Pfizer-BioNTech COVID-19 vaccination. Symptoms resolved with prednisolone treatment, suggesting a potential vaccine link, though coincidence cannot be excluded.
Area of Science:
- Immunology
- Rheumatology
- Vaccinology
Background:
- Immunoglobulin A (IgA) vasculitis, a condition often triggered by infections, has been anecdotally linked to various vaccinations.
- The Pfizer-BioNTech BNT162b2 mRNA vaccine is a widely administered COVID-19 vaccine.
Purpose of the Study:
- To report two cases of IgA vasculitis following the Pfizer-BioNTech COVID-19 vaccination.
- To investigate the potential association between mRNA COVID-19 vaccination and the development of IgA vasculitis.
Main Methods:
- Case report of two young adult males who developed symptoms post-vaccination.
- Clinical evaluation including physical examination, laboratory tests (blood counts, C-reactive protein, urinalysis), and skin biopsies.
- Immunofluorescence studies were performed on skin biopsy samples.
Main Results:
- Both patients presented with palpable purpura and arthritis after receiving the Pfizer-BioNTech vaccine.
- One patient experienced fever and gastrointestinal symptoms; urinalysis showed proteinuria and microhaematuria in this patient.
- Skin biopsies confirmed leucocytoclastic vasculitis, with IgA and C3 deposits identified in one case.
Conclusions:
- The findings suggest a possible association between the Pfizer-BioNTech mRNA vaccine and the onset of IgA vasculitis.
- Prompt treatment with prednisolone led to symptom resolution within a week.
- While a causal link is suggested, the possibility of coincidental occurrence cannot be definitively ruled out.
Keywords:
COVID-19Henoch–Schönlein purpuraIgA vasculitisautoimmune/inflammatory syndrome induced by adjuvantsmRNA vaccineMore Related Videos
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