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Updated: Oct 1, 2025
Author Spotlight: Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment
Published on: June 2, 2023
A smart probe for simultaneous imaging of the lipid/water microenvironment in atherosclerosis and fatty liver
Zixuan Zhan1, Weihua Zhuang2, Qian Lei1
1Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Precision Medicine Key Laboratory of Sichuan Province & Precision Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. wuyanmao1@sina.com.
Abstract:
A smart lipid droplet specific fluorescent probe (LDs-DM) with dual-emission in water (706 nm) and oil (535 nm) under single-excitation was prepared for revealing the ultra-structure of the aqueous and lipidic microenvironment in living cells, fatty liver tissues and atherosclerotic plaques without fluorescence emission crosstalk. This work is expected to provide inspiration for designing a novel probe with color switching ability.
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