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Related Experiment Video

Updated: Oct 1, 2025

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

Experimental laboratory biomarkers in multiple sclerosis.

Borros Arneth¹, Jörg Kraus^2,3

¹Institute of Laboratory Medicine and Pathobiochemistry, Justus Liebig University Giessen, Giessen, Germany. borros.arneth@klinchemie.med.uni-giessen.de.

Wiener Medizinische Wochenschrift (1946)

|March 7, 2022

Summary

Researchers analyzed experimental biomarkers for multiple sclerosis (MS), a central nervous system autoimmune disorder. Identifying novel MS biomarkers aids in diagnosis and disease management, improving patient outcomes.

Keywords:

Biomarkers Biomarkers in multiple sclerosis Development Disease activity Progression

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Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

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Last Updated: Oct 1, 2025

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

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Published on: September 9, 2022

Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

Published on: March 1, 2017

Area of Science:

Neurology
Immunology
Biomarker Discovery

Background:

Multiple sclerosis (MS) is a chronic autoimmune disorder affecting the central nervous system with unknown etiology.
Research is ongoing to identify reliable biomarkers for MS diagnosis and management.
This review focuses on experimental and lesser-known biomarkers for MS.

Approach:

A systematic literature review was conducted using PubMed, LILACS, and EBSCO databases.
Search terms included "multiple sclerosis," "MS," and "biomarkers."
The review analyzed studies investigating both established and novel MS biomarkers.

Key Points:

Commonly studied MS biomarkers include neurofilaments (e.g., NF-L), sCD163, CXCL13, NEO, OPN, B cells, T cells, and integrin-binding proteins.
These biomarkers show potential for aiding in the diagnosis of MS and managing its complications.
Focus is placed on biomarkers not yet widely adopted in clinical practice.

Conclusions:

Environmental and genetic factors are implicated in MS development.
A diverse range of biomarkers have been identified for MS diagnosis and management.
These biomarkers offer crucial insights for physicians to enhance clinical care and patient health outcomes in MS.