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Psychopharmacology: past, present and future
1Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
International Clinical Psychopharmacology
|March 8, 2022
Summary
Modern psychopharmacology has advanced significantly but lacks specificity. Future psychiatric treatments may involve targeted therapies like gene editing for improved efficacy and tolerability.
Area of Science:
- Psychiatry and Pharmacology
- Neuroscience
- Genetics
Background:
- Modern psychopharmacology began in the 1950s with imipramine and chlorpromazine.
- Over 100 psychiatric medications exist, yet they have limitations in efficacy and tolerability.
- Current treatments lack specificity in pharmacologic targets and brain regions.
Purpose of the Study:
- To review the evolution of psychopharmacology.
- To highlight the limitations of current psychiatric treatments.
- To explore emerging targeted therapeutic strategies for psychiatric disorders.
Main Methods:
- Review of historical developments in psychopharmacology.
- Analysis of current limitations in drug efficacy and specificity.
- Discussion of recent advancements in neuroscience, imaging, and genetics.
- Exploration of novel therapeutic modalities such as monoclonal antibodies, RNA silencing, gene editing, and drug repurposing.
Main Results:
- Despite advancements, current psychopharmacological treatments for psychiatric disorders remain suboptimal.
- New compounds with innovative mechanisms are emerging, but tissue-specific treatments are not yet available.
- Recent imaging and genetic research is identifying regional pathophysiologic mechanisms in psychiatric disorders.
Conclusions:
- A paradigm shift in psychiatric treatment is imminent.
- Targeted therapies addressing specific proteins or genes show promise.
- Innovative and precise treatments for psychiatric disorders may soon be a reality.
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