Related Experiment Video

Updated: Oct 1, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

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Correlation between Tubulointerstitial Lesion and Blood Pressure in Lupus Nephritis Patients: A Pathological,

Ruili Yuan1, Yu Zhong2, Yan Zeng1

  • 1Department of Hematology and Rheumatology Chengdu Second People's Hospital, Chengdu, China.

Kidney & Blood Pressure Research
|March 8, 2022
PubMed

Insights

Tubulointerstitial lesion (TIL) is linked to systolic blood pressure (SBP) in lupus nephritis (LN) patients. This finding highlights the importance of assessing TIL in managing LN and its associated hypertension.

Area of Science:

  • Nephrology
  • Pathology
  • Hypertension Research

Background:

  • Lupus nephritis (LN) is an autoimmune disease affecting the kidneys.
  • Understanding the pathological factors influencing blood pressure (BP) in LN is crucial for patient management.

Purpose of the Study:

  • To investigate the impact of glomerular lesion (GL), tubulointerstitial lesion (TIL), and arteriosclerotic lesion on BP in LN patients.
  • To identify specific pathological factors correlated with systolic blood pressure (SBP) in LN.

Main Methods:

  • Retrospective analysis of 69 LN patients' pathological and clinical data.
  • Assessment of GL and TIL using the 2018 ISN/RPS classification criteria.
  • Calculation of vascular lesion (VL) index and multiple linear regression analysis to determine the effect of lesions on BP, estimated glomerular filtration rate, and proteinuria.

Main Results:

  • Significant differences in TIL and VL scores were observed across different BP grades.
  • Multiple linear regression, adjusted for gender and age, revealed a significant linear correlation between TIL and SBP (p=0.022).

Conclusions:

  • Tubulointerstitial lesion (TIL) is independently associated with systolic blood pressure (SBP) in lupus nephritis (LN) patients.
  • The findings underscore the role of TIL as a predictor of hypertension in LN.
Abstract

Keywords:
Lupus nephritisSystolic blood pressureTubulointerstitial lesion

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