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A stable start: cotranslational Nt-acetylation promotes proteome stability across kingdoms

Daniel J Gibbs1, Mark Bailey2, Ross D Etherington1

  • 1School of Biosciences, University of Birmingham, Edgbaston, B15 2TT, UK.

Trends in Cell Biology
|March 9, 2022
PubMed
Summary

Cotranslational N-terminal protein acetylation (NTA) stabilizes proteins in humans and plants by blocking degradation signals. This finding contrasts with prior research, highlighting NTA

Keywords:
N terminusN-degron pathwayacetylationcotranslational modificationproteolysisproteostasis

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