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Updated: Aug 11, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Proximity-enhanced synthesis of DNA-peptide-DNA triblock molecules
Tara MacCulloch1,2, Alexandra Novacek1,2, Nicholas Stephanopoulos1,2
1School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA. nstepha1@asu.edu.
Abstract:
We report a proximity-enhanced method to synthesize a peptide flanked by two different oligonucleotide handles. Our method relies on sequential bioorthogonal reactions, and partial hybridization of the second handle to the first. We demonstrate the synthesis of a protease-responsive DNA "latch" and a cyclic bioactive peptide using this method.
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