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Esophageal motor abnormalities on high-resolution manometry in patients with scleroderma
La Tunisie Medicale
|March 9, 2022
Summary
Systemic sclerosis patients frequently exhibit absent contractility and ineffective esophageal motility. Absent contractility is linked to regurgitation and erosive esophagitis in these individuals.
Area of Science:
- Gastroenterology
- Autoimmune Diseases
- Esophageal Motility Disorders
Background:
- Systemic sclerosis (SS) is an autoimmune disorder.
- It can cause various esophageal motor disorders, including low LES pressure, absent contractility, and ineffective peristalsis.
Purpose of the Study:
- To assess esophageal motor abnormalities in SS patients using high-resolution manometry (HRM).
- To correlate manometric findings with clinical and endoscopic features.
Main Methods:
- Enrolled 49 SS patients who underwent HRM (Dec 2016-Aug 2020).
- Collected demographic and symptom data via questionnaire.
- Utilized Chicago classification criteria (V3.0) for esophageal dysmotility diagnosis.
Main Results:
- Absent contractility (49%) and ineffective motility (28.6%) were most common.
- Hypotensive LES observed in 36.7% of patients.
- Absent contractility correlated with regurgitation (p=0.013) and erosive esophagitis (p=0.003).
Conclusions:
- Absent contractility and ineffective motility are prevalent esophageal contractile patterns in SS.
- Patients with absent contractility reported more regurgitations and had higher rates of erosive esophagitis.
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