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Updated: Oct 1, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Risk Factors of Cardiac Death for Elderly Patients with Severe Chronic Kidney Disease after Percutaneous Coronary

Ying Zhang1,2,3, Guangyao Zhai1,2, Jianlong Wang1,2

  • 1Department of Cardiology, 12th ward, 12667Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|March 9, 2022
PubMed

Insights

Single-vessel disease percutaneous coronary intervention (PCI) protects elderly patients with severe chronic kidney disease (CKD) and coronary atherosclerotic heart disease (CAHD) from cardiac death. However, stable angina, lower extremity arteriosclerosis, high potassium, and no statin use increase mortality risk.

Area of Science:

  • Cardiology
  • Nephrology
  • Geriatrics

Background:

  • Elderly patients with severe chronic kidney disease (CKD) and coronary atherosclerotic heart disease (CAHD) face elevated risks after percutaneous coronary intervention (PCI).
  • Identifying specific risk factors for cardiac death in this vulnerable population is crucial for improving outcomes.

Purpose of the Study:

  • To identify independent risk factors for cardiac death in elderly patients (over 60) with severe CKD (stage 3 or above) and CAHD following PCI.
  • To determine protective factors against cardiac mortality in this patient cohort.

Main Methods:

  • A cohort of 1010 CAHD-CKD patients aged over 60 who underwent PCI were followed for at least 3 years.
  • Cardiac death cases were analyzed using univariate and logistic regression after selecting variables with P < 0.2.

Main Results:

  • Single-vessel disease (SVD) PCI was found to be a protective factor against cardiac death (OR=0.612, P=0.012).
  • Independent risk factors identified include stable angina pectoris (SAP) (OR=4.723, P=0.037), co-existing lower extremity arteriosclerosis obliterans (LEASO) (OR=2.631, P=0.009), potassium levels > 4.285 mmol/L (OR=1.44, P=0.049), and not using statins (OR=2.015, P=0.030).

Conclusions:

  • In elderly patients with severe CAHD and CKD undergoing PCI, SVD PCI is associated with a reduced risk of cardiac death.
  • Stable angina, LEASO, elevated potassium, and lack of statin therapy are significant independent risk factors for cardiac mortality in this population.

Keywords:
chronic kidney diseasecoronary atherosclerotic heart diseaseprognosisrisk factors

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