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Association Between Statin Use and Daptomycin-related Musculoskeletal Adverse Events: A Mixed Approach Combining a

Masayuki Chuma1,2, Aki Nakamoto3, Takashi Bando3

  • 1Clinical Research Center for Developmental Therapeutics, Tokushima University Hospital, Tokushima, Japan.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|March 9, 2022
PubMed
Abstract

Insights

Statin use increases the risk of daptomycin-related rhabdomyolysis, a serious muscle condition. Careful consideration of safety is crucial when prescribing statins and daptomycin together.

Area of Science:

  • Pharmacovigilance
  • Drug Safety
  • Clinical Pharmacology

Background:

  • Growing concern exists regarding musculoskeletal adverse events (MAEs) linked to combined daptomycin (DAP) and statin use.
  • The association between statin therapy and DAP-related MAEs remains controversial.
  • This study addresses the need to clarify the relationship between statin use and DAP-induced MAEs.

Purpose of the Study:

  • To investigate the association between statin use and daptomycin-related musculoskeletal adverse events (MAEs).
  • To evaluate the impact of specific statin types on DAP-related MAEs.
  • To provide evidence for safer co-prescription practices.

Main Methods:

  • A mixed-methods approach combining meta-analysis and disproportionality analysis.
  • Meta-analysis to assess the effect of statin use on DAP-related MAEs.
  • Disproportionality analysis using the US FDA Adverse Events Reporting System (FAERS) to analyze large-scale data and specific statin effects.

Main Results:

  • Meta-analysis indicated statin use significantly increased DAP-related rhabdomyolysis (OR: 3.83; 95% CI: 1.43-10.26).
  • Disproportionality analysis revealed statin use significantly increased reporting odds ratios (ROR) for DAP-related myopathy (ROR: 5.69; 95% CI: 4.31-7.51) and rhabdomyolysis (ROR: 5.77; 95% CI: 4.33-7.68).
  • Atorvastatin, rosuvastatin, and simvastatin were associated with increased incidence of DAP-related myopathy and rhabdomyolysis.

Conclusions:

  • Combined statin and daptomycin use is associated with an increased risk of DAP-related rhabdomyolysis.
  • The findings underscore the importance of careful safety considerations during co-prescription.
  • Appropriate use of statins and DAP requires vigilant monitoring for MAEs.
Keywords:
daptomycindisproportionality analysismeta-analysismusculoskeletal adverse eventstatin

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