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Neonatal thyrotoxicosis with maternal hypothyroidism

Shruthi Ravindra1, Sahana Shetty2

  • 1Department of Endocrinology, Manipal Academy of Higher Education (MAHE), Kasturba Medical College Manipal, Udupi, Karnataka, India.

BMJ Case Reports
|March 10, 2022
PubMed

Neonatal Graves' is uncommon, but a potentially fatal condition caused by transplacental transfer of thyroid stimulating immunoglobulin (TSI). It is seen in 1%-5% of infants born to a mother with Graves' disease. Here, we report a unique case of transient neonatal thyrotoxicosis with positive TSI in a premature neonate born to the mother with primary hypothyroidism. A short course of antithyroid drug treatment leads to significant clinical and biochemical improvement followed by complete recovery.

Keywords:
immunologymaterno-fetal medicineneonatal intensive carethyrotoxicosis

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