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Updated: Oct 1, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
Identifiability of causal effects with multiple causes and a binary outcome.
Dehan Kong1, Shu Yang2, Linbo Wang3
1Department of Statistical Sciences, University of Toronto,700 University Avenue, Toronto, Ontario M5G 1X6, Canada.
Unobserved confounding in observational studies can be addressed using a shared confounding model. This study demonstrates causal effect identification with a binary outcome model, overcoming limitations of previous linear Gaussian approaches.
Area of Science:
- Causal inference
- Observational studies
- Econometrics
Background:
- Unobserved confounding is a significant challenge in observational studies.
- Shared confounding, where treatments are independent given a latent confounder, has been proposed as a solution.
- Previous research indicated causal effects are unidentifiable without parametric assumptions under linear Gaussian models.
Purpose of the Study:
- To demonstrate causal effect identifiability in a shared confounding setting with a general binary choice outcome model.
- To overcome the identifiability limitations of prior linear Gaussian models.
- To propose a novel identification strategy leveraging distributional incongruence.
Main Methods:
- Utilizing a general binary choice model for the outcome with a non-probit link.
- Leveraging the incongruence between Gaussianity of treatments/latent confounder and non-Gaussianity of the latent outcome.
- Developing a two-step likelihood-based estimation procedure.
Main Results:
- The causal effect is identifiable under the specified binary outcome model, contrary to previous findings with linear Gaussian models.
- The identification strategy relies on the distributional mismatch between variables.
- A feasible two-step estimation procedure is presented.
Conclusions:
- Causal effects can be identified in shared confounding settings with non-Gaussian outcomes, even when treatments are Gaussian.
- The proposed method offers a way to address unobserved confounding in observational data.
- This research advances causal inference methodologies for complex data structures.
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