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Experimental Methods for Investigation of Shape Memory Based Elastocaloric Cooling Processes and Model Validation

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Solid-State Deracemization via Temperature Cycles in Continuous Operation: Model-Based Process Design.

Brigitta Bodák¹, Marco Mazzotti¹

¹Institute of Energy and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland.

Crystal Growth & Design

|March 10, 2022

Summary

This summary is machine-generated.

Continuous solid-state deracemization via temperature cycles offers a stable, unattended method for producing enantiopure crystals. This approach transforms batch processes into continuous operations for consistent chiral product quality.

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Area of Science:

Chemical Engineering
Crystallization Science
Chiral Chemistry

Background:

Solid-state deracemization via temperature cycles is a batch process for obtaining enantiopure compounds.
A continuous operation is needed for scalable and consistent chiral crystal production.

Purpose of the Study:

To propose and analyze continuous solid-state deracemization using mixed suspension mixed product removal crystallizers (MSMPRCs).
To compare different MSMPRC configurations for efficiency and product purity.

Main Methods:

Development of a population balance equation model for continuous operation.
Analysis of start-up and periodic steady-state behavior in three MSMPRC configurations.
Evaluation of enantiomeric excess and productivity as key performance indicators.

Main Results:

Solution-fed MSMPRCs yield pure enantiomers.
Solid and suspension-fed configurations produce highly enantiomerically enriched crystals.
An MSMPRC cascade was designed to enhance purity.

Conclusions:

Continuous solid-state deracemization is feasible in MSMPRCs.
Different configurations offer trade-offs between purity and productivity.
Guidelines are provided for transitioning batch deracemization to continuous, unattended operation.