Multiple Indolent Asymptomatic Yellow-Orange Patches and Plaques

Area of Science:

• Dermatology
• Pathology

Background:

• Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare condition characterized by amyloid deposition in the skin.
• It typically presents as localized nodules or plaques, but disseminated forms are less common.

Observation:

• An 83-year-old male presented with asymptomatic, slowly progressing yellow-orange macules and plaques on his trunk and proximal extremities over three years.
• Skin biopsy revealed eosinophilic amorphous and fissured material in the dermis, consistent with nodular amyloidosis.

Findings:

• The patient was diagnosed with disseminated primary localized cutaneous nodular amyloidosis (PLCNA) due to the widespread nature of lesions and absence of systemic symptoms.
• Diagnostic workup, including laboratory tests, did not reveal any systemic involvement.

Implications:

• This case highlights an unusual, widely distributed presentation of PLCNA, differing from more common localized variants.
• Serial monitoring is recommended due to the potential for systemic progression of the disease.