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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates
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Predicting Viable Skin Concentration: Modelling the Subpapillary Plexus.

Joshua J Calcutt1, Michael S Roberts2,3, Yuri G Anissimov4

  • 1School of Environment and Science, Griffith University, Gold Coast, Queensland, 4222, Australia.

Pharmaceutical Research
|March 10, 2022
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Summary
This summary is machine-generated.

This study enhances skin pharmacokinetic modeling by incorporating the subpapillary dermal plexus. The improved model better predicts substance concentrations in the skin, crucial for topical product safety and efficacy.

Keywords:
COMSOLComputational modellingSubpapillary plexusViable skin concentration

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Area of Science:

  • Pharmacokinetics
  • Dermal Transport Modeling
  • Mathematical Biology

Background:

  • Quantifying in vivo skin concentrations at effect sites is challenging.
  • Physiologically based mathematical modeling is essential for dermal exposure assessment.
  • Previous models did not fully account for superficial dermal vasculature.

Purpose of the Study:

  • To refine physiologically based pharmacokinetic (PBPK) and COMSOL dermal transport models.
  • To incorporate the superficial subpapillary dermal plexus into existing models.
  • To investigate the impact of dermal vasculature parameters on substance concentration.

Main Methods:

  • Developed a PBPK and COMSOL model including a subpapillary dermal plexus (two well-stirred compartments).
  • Performed sensitivity analyses to identify key transport determinants.
  • Validated the model against previously published experimental data.

Main Results:

  • The enhanced model accurately describes available experimental data, particularly at deeper dermal depths.
  • Identified subpapillary plexus size, depth, blood velocity, and vessel density as critical factors.
  • Sensitivity analyses highlighted the most important determinants of skin concentrations.

Conclusions:

  • The refined model provides a more accurate prediction of substance concentration in the skin.
  • Incorporating the subpapillary dermal plexus significantly improves dermal transport modeling.
  • This advancement aids in assessing topical treatment outcomes and dermal toxicity.