Making Chiral Salen Complexes Work with Organocatalysts.
Yu-Chao Yuan1,2, Mohamed Mellah1, Emmanuelle Schulz1
1Université Paris-Saclay, CNRS, Institut de Chimie Moléculaire et des Matériaux d'Orsay, 91405 Orsay, France.
Chemical Reviews
|March 10, 2022
Summary
Chiral salens ligands enhance asymmetric catalysis when combined with organocatalysts. This review classifies and analyzes these cooperative catalytic systems, detailing their mechanisms.
Area of Science:
- Coordination Chemistry
- Asymmetric Catalysis
- Organocatalysis
Background:
- Salen ligands derived from salicylaldehyde and chiral diamines are crucial in asymmetric organometallic catalysis.
- These ligands can cooperate with organocatalysts, acting as additives to modify metal reactivity or as true co-catalysts.
Purpose of the Study:
- To review and classify literature scenarios of salen ligands cooperating with organocatalysts.
- To elucidate the mechanistic and physical-organic chemistry principles governing these complex catalytic systems.
Main Methods:
- Literature review and classification based on the type of organocatalyst.
- Analysis of mechanistic pathways and physical-organic chemistry principles.
Main Results:
- Identification and categorization of various cooperative modes between salen ligands and organocatalysts.
- Detailed mechanistic insights into how organocatalysts influence metal-ligand complexes.
Conclusions:
- Cooperative catalysis involving chiral salen ligands and organocatalysts offers versatile strategies for asymmetric synthesis.
- Understanding the mechanistic interplay is key to designing efficient and selective catalytic systems.
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