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Improving Biocompatibility of Polyester Fabrics through Polyurethane/Gelatin Complex Coating for Potential Vascular
Wei Wang1,2,3,4, Ziyi Zhou5,6, Na Liu5
1College of Textile & Clothing, Qingdao University, 308 Ningxia Road, Qingdao 266071, China.
Polymers
|March 10, 2022
Summary
This study developed a novel vascular graft coating using polyurethane and gelatin on polyester fabric. The modified graft demonstrates improved blood compatibility and biocompatibility, crucial for medical applications.
Area of Science:
- Biomaterials Science
- Medical Device Engineering
- Tissue Engineering
Background:
- Blood compatibility is critical for vascular grafts, as they directly contact blood upon implantation.
- Coating methods offer a simple and effective way to enhance blood compatibility and prevent leakage in grafts.
- Polyester fabric provides excellent mechanical properties, but requires surface modification for improved biocompatibility.
Purpose of the Study:
- To develop a blood-compatible and biocompatible vascular graft using a multi-layer coating approach.
- To evaluate the efficacy of polyurethane and gelatin coatings on polyester fabric for vascular graft applications.
- To ensure the mechanical integrity of the vascular graft is maintained after surface modification.
Main Methods:
- Polyester fabric was coated with polyurethane to prevent blood leakage and then with gelatin to mimic the extracellular matrix.
- X-ray Photoelectron Spectroscopy (XPS) and Fourier-Transform Infrared (FTIR) spectroscopy were used for surface analysis.
- Hemolysis and platelet adhesion tests were conducted to assess anticoagulation performance.
- In vitro cell culture experiments evaluated endothelial cell proliferation and morphology.
Main Results:
- XPS and FTIR confirmed the successful coating of polyurethane and gelatin on the polyester fabric.
- Hemolysis tests showed minimal red blood cell damage, and reduced platelet adhesion indicated good anticoagulation.
- In vitro studies demonstrated excellent endothelial cell proliferation and morphology on the modified fabric.
- The mechanical properties of the polyester fabric were preserved after the coating process.
Conclusions:
- The developed polyester fabric coated with polyurethane and gelatin exhibits promising blood compatibility and biocompatibility.
- This multi-layer coating strategy is effective for creating advanced vascular grafts.
- The modified grafts meet essential mechanical requirements for vascular applications, suggesting significant clinical potential.
