The Gut Microbiome, Seleno-Compounds, and Acute Myocardial Infarction
Fu-Chun Chiu1, Chin-Feng Tsai2,3, Pang-Shuo Huang1
1Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Dou-Liu City 640, Taiwan.
Abstract:
Background: Gut microbiome alterations might be considered a metabolic disorder. However, the relationship between the microbiome and acute myocardial infarction (AMI) has not been properly validated. Methods: The feces of 44 subjects (AMI: 19; control: 25) were collected for fecal genomic DNA extraction. The variable region V3−V4 of the 16S rRNA gene was sequenced using the Illumina MiSeq platform. The metabolite amounts were analyzed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways. Results: The bacteria were more enriched in the AMI group both in the observed operational taxonomic units (OTUs) and faith phylogenetic diversity (PD) (p-value = 0.01 and <0.001 with 95% CI, individually). The Selenomonadales were less enriched in the AMI group at the family, genus, and species levels (all linear discriminant analysis (LDA) scores > 2). Seleno-compounds were more abundant in the AMI group at the family, genus, and species levels (all LDA scores > 2). Conclusions: This is the first study to demonstrate the association of Selenomonadales and seleno-compounds with the occurrence of AMI. Our findings provide an opportunity to identify a novel approach to prevent and treat AMI.
Insights
Gut microbiome alterations are linked to acute myocardial infarction (AMI). This study found Selenomonadales bacteria and seleno-compounds are associated with AMI, offering new prevention and treatment avenues.
Area of Science:
- Microbiology
- Metabolic Disorders
- Cardiovascular Disease
Background:
- Gut microbiome dysbiosis is increasingly recognized as a factor in metabolic disorders.
- The specific role of the gut microbiome in acute myocardial infarction (AMI) requires further validation.
Purpose of the Study:
- To investigate the association between gut microbial composition and metabolic pathways in patients with AMI.
- To identify specific bacterial taxa and metabolites linked to the occurrence of AMI.
Main Methods:
- Fecal samples from 44 subjects (19 AMI, 25 controls) were analyzed.
- 16S rRNA gene sequencing (V3-V4 region) was performed using Illumina MiSeq.
- Metabolite analysis utilized Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways.
Main Results:
- Increased bacterial richness and diversity (OTUs, Faith PD) were observed in the AMI group.
- The abundance of Selenomonadales (family, genus, species) was significantly lower in AMI patients.
- Conversely, seleno-compounds were more abundant in the AMI group.
Conclusions:
- This study is the first to link Selenomonadales and seleno-compounds to AMI occurrence.
- Findings suggest a potential role for these microbial and metabolic factors in AMI pathogenesis.
- This research opens avenues for novel diagnostic and therapeutic strategies for AMI.
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