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Related Experiment Videos

Drug Design-Past, Present, Future.

Irini Doytchinova1

  • 1Drug Design and Bioinformatics Lab, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.

Molecules (Basel, Switzerland)
|March 10, 2022
PubMed
Summary
This summary is machine-generated.

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Drug design, a cornerstone of pharmaceutical science, has evolved significantly since the 19th century. Modern drug discovery leverages advanced technologies, including artificial intelligence, for creating safer and more effective medications.

Area of Science:

  • Pharmaceutical Science
  • Medicinal Chemistry
  • Drug Discovery

Background:

  • The concept of drug-receptor interaction, likened to a 'key and lock' mechanism, was proposed by Emil Fischer in the late 19th century.
  • Drug design has evolved into a structured scientific discipline with a robust theoretical foundation and practical applications.

Approach:

  • Modern drug design employs a wide array of scientific and technological innovations.
  • Artificial intelligence is increasingly accelerating progress in drug design and discovery.

Key Points:

  • The primary objective of drug design is the discovery of drugs that are effective, specific, non-toxic, safe, and well-tolerated.
  • This review highlights key developmental milestones, current methodologies, and future prospects in drug design.
Keywords:
QSARartificial intelligencedrug designdrug discovery and developmentmolecular dockingmolecular dynamicsvirtual screening

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  • It serves as an introduction to the Special Issue on 'Drug Design-Science and Practice' in the journal *Molecules*.

    • Conclusions:

    • Drug design represents a highly dynamic field, integrating cutting-edge science and technology.
    • The continuous advancement in drug design is crucial for developing next-generation therapeutics.