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Quantification of Atherosclerosis in Mice
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Vaccination against Atherosclerosis: Is It Real?

Anastasia V Poznyak1, Evgeny E Bezsonov2,3,4, Tatyana V Popkova5

  • 1Institute for Atherosclerosis Research, Skolkovo Innovative Center, 121609 Moscow, Russia.

International Journal of Molecular Sciences
|March 10, 2022
PubMed

Insights

Atherosclerosis, a vascular disease linked to diet and lifestyle, may be preventable with vaccines targeting the immune response. Research explores immune involvement in atherogenesis for potential cardiovascular risk reduction.

Area of Science:

  • Immunology
  • Cardiovascular Medicine
  • Pathology

Background:

  • Atherosclerosis is a long-recognized vascular disease often linked to lifestyle factors and prevalent in developed nations.
  • While treatments exist, prevention strategies like vaccination are crucial for reducing mortality.
  • Understanding the immune system's role is key to developing novel preventive measures.

Purpose of the Study:

  • To review the involvement of immune responses in the development of atherosclerotic lesions.
  • To discuss modern concepts of atherogenesis and immune inflammation in atherosclerosis.
  • To identify potential vaccine targets for preventing atherosclerosis and reducing cardiovascular risk.

Main Methods:

  • Literature review of experimental and clinical data.
  • Analysis of modern concepts in atherogenesis and immune inflammation.
  • Evaluation of potential immune targets for vaccine development.

Main Results:

  • The immune response plays a significant role in the pathogenesis of atherosclerotic lesions.
  • Immune inflammation is a key component of atherosclerosis development.
  • Several potential targets for immune-based therapies and vaccines have been identified.

Conclusions:

  • Vaccination strategies targeting the immune system offer a promising avenue for atherosclerosis prevention.
  • Immune therapies hold potential for reducing cardiovascular risk associated with atherosclerosis.
  • Further research into immune mechanisms is essential for developing effective vaccines and treatments.

Keywords:
CVDatherosclerosisimmunityvaccination

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