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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Other Disorders of Digestive System01:30

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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

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Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
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Related Experiment Video

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Fragility Assessment of Bovine Cortical Bone Using Scratch Tests
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Bone Fragility in Gastrointestinal Disorders.

Daniela Merlotti1, Christian Mingiano2, Roberto Valenti3

  • 1Department of Medical Sciences, Azienda Ospedaliera Universitaria Senese, 53100 Siena, Italy.

International Journal of Molecular Sciences
|March 10, 2022
PubMed
Summary

Osteoporosis, a bone disease increasing fracture risk, is linked to gastrointestinal disorders. This review explores how gut health impacts bone density and fragility.

Keywords:
Helicobacter pyloriceliac diseasechronic gastritis and peptic ulcer diseasedysbiosisgastric cancer and gastrectomyinflammatory bowel diseaseosteoporosis

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Orthopedics

Background:

  • Osteoporosis is a prevalent skeletal disease marked by low bone mass and strength, elevating fracture risk.
  • Estrogen decline during menopause is a key factor in women, while men can also develop osteoporosis due to various conditions or treatments.
  • The skeletal implications of many gastrointestinal diseases are often underestimated, despite the gut's crucial role in nutrient absorption and overall health.

Purpose of the Study:

  • To critically review the role of major gastrointestinal disorders in the development of osteoporosis.
  • To highlight the underappreciated contribution of gastrointestinal diseases to bone fragility and fractures.
  • To provide an updated understanding of the gut-bone axis in osteoporosis pathogenesis.

Main Methods:

  • Literature review and critical analysis of existing studies.
  • Synthesis of current research on gastrointestinal diseases and their skeletal consequences.
  • Focus on the mechanisms linking gut health to bone metabolism.

Main Results:

  • Gastrointestinal health is essential for nutrient absorption (e.g., calcium, vitamins) vital for bone.
  • Impaired gastrointestinal barrier function and dysbiosis can negatively impact bone health.
  • Chronic gastrointestinal diseases likely have profound implications for osteoporosis development and progression.

Conclusions:

  • Gastrointestinal disorders significantly contribute to osteoporosis pathogenesis and bone fragility.
  • Recognizing the gut-bone axis is crucial for managing and preventing osteoporosis.
  • Further investigation into the skeletal effects of gastrointestinal diseases is warranted.