Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Sep 30, 2025

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:17

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

453

Wound-Microenvironment Engineering through Advanced-Dressing Bioprinting.

Cristina Del Amo1, Xabier Fernández-San Argimiro2, María Cascajo-Castresana2

  • 1Regenerative Therapies, Bioprinting Laboratory, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, 48903 Barakaldo, Spain.

International Journal of Molecular Sciences
|March 10, 2022
PubMed
Summary

Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

6.6K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Teaching and evolution in surgical planning of robotic partial nephrectomy with 3D printing models.

Journal of robotic surgery·2025
Same author

Influence of Platelet Concentration on the Clinical Outcome of Platelet-Rich Plasma Injections in Knee Osteoarthritis: Letter to the Editor.

The American journal of sports medicine·2025
Same author

Assessing Bioprinted Functionalized Grafts for Biological Tendon Augmentation In Vitro.

International journal of molecular sciences·2024
Same author

Sonographic pathoanatomy of greater trochanteric pain syndrome.

Journal of ultrasound·2023
Same author

Implementation of an In-House 3D Manufacturing Unit in a Public Hospital's Radiology Department.

Healthcare (Basel, Switzerland)·2022
Same author

Enhanced Adipogenic Differentiation of Human Dental Pulp Stem Cells in Enzymatically Decellularized Adipose Tissue Solid Foams.

Biology·2022
This summary is machine-generated.

This study engineered advanced wound dressings using bioprinting techniques. These novel dressings promote cell growth and activate wound healing mechanisms, offering a new strategy for chronic wound management.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Chronic wounds pose a significant economic burden on healthcare systems.
  • Engineering the cellular microenvironment is crucial for promoting wound healing.
  • Advanced wound dressings are needed to accelerate healing in patients with comorbidities.

Purpose of the Study:

  • To develop and characterize novel composite bioinks for advanced wound dressings.
  • To investigate the potential of engineered microenvironments in activating cellular wound-healing mechanisms.
  • To assess the impact of bioink composition on cell viability, proliferation, and paracrine signaling.

Main Methods:

  • Extrusion bioprinting of composite bioinks formulated from adipose-derived decellularized extracellular matrix, plasma, and human dermal fibroblasts.
Keywords:
3D bioprintingbioinkcytokinesdecellularized adipose extracellular matrixgrowth factorsplasmaplateletwound healing

More Related Videos

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies
08:31

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Published on: May 19, 2022

4.1K
Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

16.0K

Related Experiment Videos

Last Updated: Sep 30, 2025

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:17

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

453
Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies
08:31

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Published on: May 19, 2022

4.1K
Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
08:22

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids

Published on: August 11, 2017

16.0K
  • Rheological and microstructural analysis of hydrogel properties.
  • Assessment of embedded fibroblast viability, proliferation, and extracellular matrix protein expression (collagens, fibronectin).
  • ELISA and multiplex protein array analyses to evaluate paracrine factor release and bioinformatic analysis.
  • Stimulation of human dermal cells with conditioned media from the engineered dressings.

    • Main Results:

    • The composite hydrogels demonstrated favorable rheological properties supporting cell viability and proliferation.
    • Embedded fibroblasts maintained expression of key extracellular matrix proteins.
    • Paracrine signaling associated with wound healing, including modulation of inflammation and angiogenesis, was identified.
    • Dressing modalities with varying platelet concentrations influenced the release of key cytokines (IL-8, MCP-1, VEGF, HGF).
    • Conditioned media promoted human dermal cell proliferation.

    Conclusions:

    • Engineered microenvironments using bioprinted composite dressings can enhance wound healing.
    • The developed bioinks support cell function and promote pro-healing paracrine signaling.
    • This approach offers a promising strategy for developing advanced therapies for chronic wounds.