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Total-body PET/CT - First Clinical Experiences and Future Perspectives
Quinn Kwan-Tai Ng1, Elizabeth Katherine Anna Triumbari2, Negar Omidvari3
1Department of Radiology, UC Davis, Sacramento, CA, USA.
Seminars in Nuclear Medicine
|March 11, 2022
Summary
Total-body PET scanners offer enhanced sensitivity and lesion detection, enabling faster scans, lower radiation doses, and improved image quality. While challenges exist, this technology advances diagnostic capabilities for various clinical applications.
Area of Science:
- Medical Imaging
- Nuclear Medicine
- Radiology
Background:
- Total-body PET scanners with long axial fields of view are now commercially available.
- These scanners offer significant gains in signal collection efficiency and spatial resolution compared to conventional PET/CT.
Purpose of the Study:
- To highlight the advancements and clinical applications of total-body PET technology.
- To discuss the benefits and challenges associated with the increased sensitivity and capabilities of total-body scanners.
Main Methods:
- Review of the capabilities and applications of total-body PET scanners.
- Discussion of image acquisition, radiotracer utilization, and interpretation considerations.
Main Results:
- Total-body PET allows for reduced acquisition times, lower administered radiotracer activity, and delayed scanning for improved lesion detection.
- Enhanced image quality, simultaneous total-body dynamic imaging, and multiparametric data acquisition are key benefits.
- Potential challenges include increased false positives, logistical issues with delayed scans, and data processing demands.
Conclusions:
- Total-body PET significantly enhances diagnostic capabilities, offering improved sensitivity, reduced patient dose, and novel imaging applications.
- Addressing challenges in interpretation and data management will be crucial for widespread clinical adoption.
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