Related Experiment Video
Updated: Sep 30, 2025
09:15
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
14.8K
Relationship between subclasses low-density lipoprotein and carotid plaque
Zhanhai Pan1, Huiwen Guo1, Qingqing Wang1
1Department of Neurology, Affiliated Hospital of Chengde Medical College, Chengde City, Hebei Province, China.
Translational Neuroscience
|March 11, 2022
Summary
Low-density lipoprotein (LDL) subclasses, specifically LDL-1 and LDL-3, are linked to carotid plaque stability. Higher LDL-1 levels correlate with stable plaques, while elevated LDL-3 indicates unstable plaques.
Area of Science:
- Cardiovascular Research
- Lipid Metabolism
- Atherosclerosis Research
Background:
- Atherosclerotic plaques can develop even with normal low-density lipoprotein (LDL) cholesterol levels.
- Understanding LDL subclasses is crucial for assessing plaque stability.
- This study investigates the role of different LDL subclasses in carotid plaque stability.
Purpose of the Study:
- To determine the relationship between LDL subclass content and carotid plaque stability.
- To identify specific LDL subclasses associated with stable versus unstable atherosclerotic plaques.
- To explore LDL subclasses as potential biomarkers for plaque instability.
Main Methods:
- Carotid plaque stability was assessed using ultrasound, categorizing patients into stable (n=37) and unstable (n=41) groups.
- LDL subclasses were quantified using the LIPOPRINT system.
- Clinical data including age, glycosylated hemoglobin (Ghb), homocysteine (Hcy), total cholesterol (TC), LDL cholesterol, and triglyceride (TG) were collected.
Main Results:
- LDL-1 and LDL-2 subclass levels were significantly higher in the stable plaque group (p < 0.05).
- LDL-3, LDL-4, and small dense LDL (sd-LDL) levels were significantly higher in the unstable plaque group (p < 0.05).
- LDL-1 subclass (adjusted OR = 0.923, p < 0.05) and LDL-3 subclass (adjusted OR = 1.176, p < 0.05) were identified as independent risk factors for plaque stability.
Conclusions:
- Elevated LDL-1 subclass levels are associated with stable carotid plaques.
- Increased LDL-3 subclass levels are linked to unstable carotid plaques.
- Specific LDL subclasses may serve as indicators of atherosclerotic plaque stability.
More Related Videos
11:00A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
Published on: June 22, 2010
28.9K
13:45A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
Published on: November 11, 2022
2.2K
Related Concept Videos
01:30Atherosclerosis I: Introduction
142
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
142
01:26Coronary Artery Disease II: Pathophysiology
69
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
69
01:30Coronary Artery Disease I: Introduction
163
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
163
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
314
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
314
01:26Atherosclerosis III: Management
56
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
56
01:26Coronary Artery Disease IV: Preventive Measures
113
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
113