Related Experiment Video

Updated: Sep 30, 2025

An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

659

Hypercoagulopathy in Overweight and Obese COVID-19 Patients: a Single-Center Case Series

Azza Sarfraz1,2, Zouina Sarfraz1,3, Aman Siddiqui1,4

  • 1Larkin Health System, South Miami, FL, USA.

Journal of Critical Care Medicine (Universitatea De Medicina Si Farmacie Din Targu-Mures)
|March 11, 2022
PubMed

Insights

Overweight patients with COVID-19 experienced severe coagulopathy, leading to fatal bleeding and thromboembolism. Understanding this hypercoagulable state is crucial for improving outcomes in obese individuals.

Area of Science:

  • Internal Medicine
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Overweight and obesity are prevalent risk factors for severe COVID-19.
  • COVID-19 is associated with a prothrombotic state, termed coagulopathy.
  • The specific coagulopathic manifestations in obese COVID-19 patients remain under-characterized.

Purpose of the Study:

  • To describe the clinical presentation and outcomes of hypercoagulable states in overweight or obese patients with COVID-19.
  • To highlight the atypical features of COVID-19-associated coagulopathy in this patient group.
  • To emphasize the need for further research into the pathophysiology of coagulopathy in obese COVID-19 patients.

Main Methods:

  • A case series of five overweight or obese patients with confirmed COVID-19 was analyzed.
  • Coagulation parameters were assessed to identify hypercoagulable states.
  • Clinical manifestations, including bleeding and thromboembolism, were documented.

Main Results:

  • All five patients exhibited multiple coagulation abnormalities indicative of a hypercoagulable state.
  • Manifestations included disseminated intravascular coagulation, venous thromboembolism, gastrointestinal bleeding, and retroperitoneal hematoma.
  • All patients required intensive care unit admission and ultimately died.

Conclusions:

  • Overweight and obese patients with COVID-19 can present with severe, atypical coagulopathy.
  • The observed hypercoagulable state is associated with high mortality.
  • Further investigation into the pathophysiology is essential for developing targeted treatments and improving clinical outcomes in this vulnerable population.

Keywords:
Coronavirus disease 2019D-dimercovid-19-associated coagulopathydisseminated intravascular coagulationheparinobesityvenous thromboembolism

More Related Videos

Multidisciplinary Approach to Obesity Management: A Case Report05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

420
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

25.5K

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
51
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
662
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
963
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:  
748
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
56
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
60