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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
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Hyperbaric oxygen therapy: when pressure is good for diabetic foot ulcers
Rutger Lalieu1, René Bol Raap2, Rob van Hulst3
1Hyperbaar Geneeskundig Centrum, Rijswijk, the Netherlands, and Amsterdam University Medical Centers, location AMC, Department of Anaesthesiology.
British Journal of Community Nursing
|March 11, 2022
Summary
Hyperbaric oxygen therapy (HBOT) shows promise for healing diabetic foot ulcers (DFUs) that resist conventional treatment. This safe therapy may improve healing and reduce amputation risk by addressing key factors like hypoxia.
Area of Science:
- Biomedical Engineering
- Wound Healing Research
- Hyperbaric Medicine
Background:
- Diabetic foot ulcers (DFUs) are a significant complication of diabetes, with up to 35% failing to heal despite treatment.
- Chronic wound healing is impaired by aging, ischemia-reperfusion injury, bacterial colonization, and hypoxia.
- Oxygen is critical for all wound-healing processes.
Purpose of the Study:
- To evaluate the efficacy of hyperbaric oxygen therapy (HBOT) in improving wound healing for non-healing DFUs.
- To assess HBOT's potential to correct the four primary pathophysiological factors contributing to chronic wounds.
Main Methods:
- Review of clinical trials and systematic reviews on HBOT for DFUs.
- Analysis of HBOT's impact on wound healing rates and amputation risk.
- Consideration of patient subgroups, including those with and without peripheral arterial occlusive disease (PAOD).
Main Results:
- HBOT demonstrates a positive trend in enhancing DFU healing.
- Studies indicate a reduced risk of amputation associated with HBOT.
- Contradictory results may stem from inconsistent patient group selection (PAOD vs. non-PAOD).
Conclusions:
- Hyperbaric oxygen therapy is an internationally recognized treatment option for non-healing DFUs.
- HBOT is generally safe, with typically mild and transient side effects.
- Further research may clarify optimal patient selection to resolve study controversies.
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