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Effects of polyphenols on ncRNAs in cancer-An update

Vishnu Priya Veeraraghavan1, Ullas Mony1, Kaviyarasi Renu1

  • 1Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Clinical and Experimental Pharmacology & Physiology
|March 11, 2022
PubMed

Insights

Plant polyphenols show anti-tumour effects in cancer by modulating long non-coding RNAs (lncRNAs). These interactions may involve epigenetic modifications and signalling pathways, offering new therapeutic strategies for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Plant polyphenols are increasingly recognized for their potential anti-tumour effects in various cancers.
  • The precise regulatory mechanisms underlying polyphenol efficacy in cancer remain largely undetermined.
  • Long non-coding RNAs (lncRNAs) are emerging as critical regulators in tumorigenesis and cancer progression.

Purpose of the Study:

  • To review the modulatory effects of lncRNAs in cellular processes relevant to cancer.
  • To discuss the mechanisms of action of plant polyphenols in cancer therapy.
  • To explore the potential interaction between polyphenols and lncRNAs in cancer intervention.

Main Methods:

  • Literature review of existing research on plant polyphenols, lncRNAs, and cancer.
  • Analysis of studies investigating the roles of lncRNAs in tumorigenesis and cellular processes.
  • Examination of proposed mechanisms for polyphenol-induced anti-cancer effects, including epigenetic modifications and signalling pathway interactions.

Main Results:

  • Polyphenols may exert anti-cancer effects through epigenetic modifications and interactions with cellular signalling pathways.
  • lncRNAs are implicated in the initiation, development, and progression of various cancers.
  • Specific polyphenols may target certain lncRNAs, mediating therapeutic effects via critical cancer intervention signalling pathways.

Conclusions:

  • Plant polyphenols hold promise as anti-cancer agents, potentially acting through the modulation of lncRNAs.
  • The interaction between polyphenols and lncRNAs represents a potential therapeutic strategy for cancer treatment.
  • Further research is warranted to elucidate the specific molecular mechanisms underlying polyphenol-lncRNA interactions in oncotherapy.
Keywords:
EGCGcurcuminlncRNAsoncotherapypolyphenolsresveratroltumorigenesis

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