Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids

Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids

Diols are compounds with two hydroxyl groups. In addition to syn dihydroxylation, diols can also be synthesized through the process of anti dihydroxylation. The process involves treating an alkene with a peroxycarboxylic acid to form an epoxide. Epoxides are highly strained three-membered rings with oxygen and two carbons occupying the corners of an equilateral triangle. This step is followed by ring-opening of the epoxide in the presence of an aqueous acid to give a trans diol.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of the Edible Microalga <i>Chlorella</i> on Gut Microbiota and on Brain Health: Current Evidence and Emerging Links.

Nutrients·2026

Same author

The Effect of Ultra-Processed Food Consumption and Physical Activity on Fatty Acid Profiles in Young Muslims in Melilla.

Healthcare (Basel, Switzerland)·2026

Same author

Evaluation of the predictive accuracy of QUICKI and McAuley indices for insulin resistance in adolescents: Insights from a cross-sectional study.

PloS one·2026

Same author

A Western-Style Breakfast Induces a More Pro-Inflammatory Postprandial Response and Promotes Greater Macrophage Lipid Accumulation Compared to a Mediterranean-Style Breakfast in Obese and Normal-Weight Individuals.

Nutrients·2026

Same author

Consumption of Ultra-Processed Foods and Biochemical Markers Predictive of Type 2 Diabetes Mellitus in a Self-Selected Pilot Sample of Muslim Adolescents in Melilla.

Foods (Basel, Switzerland)·2026

Same author

Fecal Short-Chain Fatty Acids to Predict Prediabetes and Type 2 Diabetes Risk: An Exploratory Cross-Sectional Study.

Nutrients·2025

Same journal

RETRACTED: Dal Monte et al. Fatty Acids Dietary Supplements Exert Anti-Inflammatory Action and Limit Ganglion Cell Degeneration in the Retina of the EAE Mouse Model of Multiple Sclerosis. <i>Nutrients</i> 2018, <i>10</i>, 325.

Nutrients·2026

Same journal

RETRACTED: Cammalleri et al. A Dietary Combination of Forskolin with Homotaurine, Spearmint and B Vitamins Protects Injured Retinal Ganglion Cells in a Rodent Model of Hypertensive Glaucoma. <i>Nutrients</i> 2020, <i>12</i>, 1189.

Nutrients·2026

Same journal

RETRACTED: Locri et al. Protective Efficacy of a Dietary Supplement Based on Forskolin, Homotaurine, Spearmint Extract, and Group B Vitamins in a Mouse Model of Optic Nerve Injury. <i>Nutrients</i> 2019, <i>11</i>, 2931.

Nutrients·2026

Same journal

Correction: Pramesthi et al. Evaluating the Impact of Indonesia's National School Feeding Program (ProGAS) on Children's Nutrition and Learning Environment: A Mixed-Methods Approach. <i>Nutrients</i> 2025, <i>17</i>, 3575.

Nutrients·2026

Same journal

Correction: Huang et al. Correlation Study Between Dietary Behaviors, Lifestyle, and Psychological Problems in Chinese Children Aged 3-7. <i>Nutrients</i> 2025, <i>17</i>, 176.

Nutrients·2026

Same journal

Association of Dietary Animal and Plant Protein Composition with All-Cause Mortality: 24-Year Population-Based Cohort Study.

Nutrients·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 30, 2025

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

Published on: November 17, 2011

Oleanolic Acid: Extraction, Characterization and Biological Activity.

José M Castellano¹, Sara Ramos-Romero², Javier S Perona¹

¹Department of Food and Health, Instituto de la Grasa-CSIC, Campus of the University Pablo de Olavide, Building 46, 41013 Seville, Spain.

|March 12, 2022

Summary

This summary is machine-generated.

Oleanolic acid, a plant compound, shows promise for treating various diseases like diabetes and cancer due to its diverse biological activities. Research is exploring its extraction and therapeutic potential, addressing its poor water solubility for better drug delivery.

Keywords:

biological activities characterization diseases mechanisms oleanolic acid structure

More Related Videos

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria

Published on: February 28, 2025

OLIgo Mass Profiling OLIMP of Extracellular Polysaccharides

OLIgo Mass Profiling OLIMP of Extracellular Polysaccharides

Published on: June 20, 2010

Related Experiment Videos

Last Updated: Sep 30, 2025

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis

Published on: November 17, 2011

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria

Published on: February 28, 2025

OLIgo Mass Profiling OLIMP of Extracellular Polysaccharides

OLIgo Mass Profiling OLIMP of Extracellular Polysaccharides

Published on: June 20, 2010

Area of Science:

Phytochemistry
Pharmacology
Medicinal Chemistry

Background:

Oleanolic acid is a pentacyclic triterpenoid found widely in plants.
It exhibits a broad spectrum of biological activities, including anti-diabetic, anti-cancer, anti-inflammatory, and hepatoprotective effects.
Its therapeutic potential is hindered by poor water solubility, necessitating strategies to improve biopharmaceutical properties.

Purpose of the Study:

To review current knowledge on oleanolic acid extraction and characterization.
To summarize its diverse biological activities and underlying mechanisms of action.
To highlight research progress in enhancing its therapeutic applications.

Main Methods:

Literature review of scientific publications.
Analysis of studies on oleanolic acid extraction and characterization techniques.
Synthesis of research findings on biological activities and mechanisms.

Main Results:

Oleanolic acid demonstrates significant potential in managing dyslipidemia, diabetes, and metabolic syndrome.
It possesses antiviral, antibacterial, antifungal, anti-cancer, anti-inflammatory, and hepatoprotective properties.
Ongoing research focuses on overcoming its hydrophobic nature to improve bioavailability.

Conclusions:

Oleanolic acid is a promising natural compound with multifaceted therapeutic potential.
Further research into its extraction, characterization, and formulation is crucial for clinical translation.
Addressing its solubility challenges is key to unlocking its full medicinal value.