The odontogenic keratocyst revisited

Area of Science:

• Oral pathology
• Dentoalveolar surgery
• Cystic lesion research

Background:

• Odontogenic keratocysts (OKCs) are developmental cysts with a high recurrence rate.
• Understanding the etiology and pathogenesis of OKCs is crucial for effective treatment strategies.
• Nevoid basal cell carcinoma syndrome (NBCCS) is associated with multiple OKCs, highlighting genetic influences.

Approach:

• Review of current literature on OKC treatment.
• Analysis of the role of the dental lamina in OKC development.
• Discussion of submucosal hamartias in the context of NBCCS and OKCs.

Key Points:

• The dental lamina is implicated in the pathogenesis of odontogenic keratocysts.
• Submucosal hamartias are frequently observed in patients with nevoid basal cell carcinoma syndrome.
• Recurrence rates of OKCs necessitate a thorough understanding of their origins.

Conclusions:

• Treatment protocols for odontogenic keratocysts should consider their specific etiology and pathogenesis.
• Further research into the developmental pathways of OKCs may lead to improved therapeutic approaches.
• Management of OKCs in NBCCS patients requires a multidisciplinary approach.