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Deep tissue localization and sensing using optical microcavity probes.

Aljaž Kavčič1, Maja Garvas1,2, Matevž Marinčič1,3

  • 1Department of Condensed Matter Physics, J. Stefan Institute, Jamova 39, SI-1000, Ljubljana, Slovenia.

Nature Communications
|March 12, 2022
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Summary
This summary is machine-generated.

Optical microcavity probes enable deep-tissue, single-cell imaging and environmental sensing. Their unique spectral modes overcome scattering, offering versatile biological insights beyond traditional fluorescent labels.

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Area of Science:

  • Biophotonics
  • Cellular Imaging
  • Biosensing

Background:

  • Optical microcavities and microlasers offer spectrally narrow emission and high sensitivity for biological probes.
  • Imaging at single-cell resolution in scattering biological tissues beyond the ballistic light transport regime is challenging.

Purpose of the Study:

  • To demonstrate the capability of optical microcavity probes for deep-tissue, 3D localization and tracking of individual cells.
  • To showcase the use of microcavities for sensing cellular environments and parameters.

Main Methods:

  • Utilizing whispering-gallery modes of optical microcavities embedded within cells.
  • Leveraging spectral features unaffected by tissue scattering, absorption, and autofluorescence for signal detection.
  • Functionalizing microcavities for simultaneous sensing of parameters like temperature and pH.

Main Results:

  • Achieved 3D localization and tracking of individual cells at depths beyond the light transport length.
  • Demonstrated environmental sensing capabilities within living cells.
  • Showcased microcavity versatility exceeding standard fluorescent labels.

Conclusions:

  • Optical microcavity probes enable robust, deep-tissue imaging and sensing at single-cell resolution.
  • Whispering-gallery modes provide a scattering-resistant imaging modality for biological applications.
  • Functionalized microcavities offer a versatile platform for multi-parameter biosensing.