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Submental fat reduction using sequential treatment approach with cryolipolysis and ATX-101
H Ray Jalian1, Rebecca Fitzgerald1, Beta Bowen2
1Rebecca Fitzgerald Dermatology, Los Angeles, California, USA.
Journal of Cosmetic Dermatology
|March 12, 2022
Summary
Sequential treatment using cryolipolysis and ATX-101 effectively reduced severe submental fat (SMF), improving patient satisfaction and aesthetics with minimal side effects.
Area of Science:
- Aesthetics and Body Contouring
- Dermatology and Plastic Surgery
Background:
- Submental fat (SMF) negatively impacts facial aesthetics and self-image.
- Effective and safe reduction of SMF is a significant clinical goal.
Purpose of the Study:
- To assess the safety, effectiveness, and patient satisfaction of sequential cryolipolysis and ATX-101 for SMF reduction.
- To evaluate the combined treatment's impact on clinician- and patient-reported outcomes.
Main Methods:
- Prospective, open-label, single-site study.
- Enrolled participants with Grade 4 (extreme) SMF.
- Assessed outcomes using Clinician-Rated SMF Rating Scale (CR-SMFRS), ultrasound fat thickness, and Subject Self-Rating Scale (SSRS) at 12 weeks post-treatment.
Main Results:
- 100% of participants achieved at least a 1-grade improvement on CR-SMFRS; 71.4% achieved ≥2-grade improvement.
- 71.4% of participants reported satisfaction scores of 4 or higher.
- Adverse events were mild, transient, and no serious adverse events occurred.
Conclusions:
- Sequential cryolipolysis and ATX-101 is a safe and effective treatment for severe submental fat.
- The combination therapy demonstrated significant improvements in both objective and subjective measures.
- High patient satisfaction was achieved with a favorable safety profile.
