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Updated: Sep 30, 2025

IridiumIII Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II
Published on: July 7, 2015
An ultra-sensitive near-infrared fluorescent probe based on triphenylamine with high selectivity detecting the
Mingming Liu1, Jian Cao1, Yajing Tu1
1School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai, 201620, PR China.
Abstract:
In this work, a novel triphenylamine derivative probe TPA-1 was designed and synthesized with a mechanism of aggregation induced emission (AIE) and twisted intramolecular charge transfer (TICT) in a microenvironment. It can be used for the detection of keratin with AIE enhanced characterization in near infrared (NIR) emission. The sensitivity and selectivity for keratin detection were also studied. In the physiological pH range, the detection of TPA-1 to keratin was not interfered by other proteins and amino acids, and had excellent specificity and photostability. TPA-1 can also be used for viscosity detection.

