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Updated: Sep 30, 2025

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
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Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

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Cardioprotective Properties of Phenolic Compounds: A Role for Biological Rhythms

Cristina Torres-Fuentes1, Manuel Suárez1, Gerard Aragonès1

  • 1Nutrigenomics Research Group, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Tarragona, 43007, Spain.

Molecular Nutrition & Food Research
|March 13, 2022
PubMed

Insights

Phenolic compounds may offer safer cardiovascular disease (CVD) treatments by modulating biological rhythms. This review explores their potential to reduce CVD risk factors influenced by circadian rhythms.

Area of Science:

  • Pharmacology and Chronobiology
  • Cardiovascular Research

Background:

  • Cardiovascular diseases (CVD) are a leading global cause of death, with increasing prevalence.
  • Current CVD treatments have limitations and side effects, necessitating novel therapeutic approaches.
  • Phenolic compounds exhibit cardioprotective effects, targeting CVD risk factors like inflammation and hypertension.

Purpose of the Study:

  • To review the potential of phenolic compounds as therapeutics for cardiovascular diseases.
  • To explore the role of biological rhythms in modulating CVD risk factors and phenolic compound efficacy.
  • To highlight the significance of chronotherapy in cardiovascular health.

Main Methods:

  • Literature review focusing on phenolic compounds, cardiovascular diseases, and biological rhythms.
  • Analysis of studies investigating the influence of circadian rhythms on CVD pathogenesis.
  • Examination of research on the time-dependent effects of phenolic compounds.

Main Results:

  • Biological rhythms significantly influence metabolic and physiological processes relevant to CVD.
  • Circadian rhythm disruption is associated with increased CVD events.
  • The efficacy of phenolic compounds can be modulated by administration timing and photoperiod.

Conclusions:

  • Phenolic compounds show promise as safer therapeutic agents for CVD prevention.
  • Leveraging biological rhythms offers a novel strategy for enhancing the cardioprotective effects of phenolics.
  • Chronomodulated administration of phenolic compounds could optimize CVD management.

Keywords:
cardiovascular diseasescircadian rhythmsendothelial functionoxidative stresspolyphenols

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