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Updated: Sep 30, 2025

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

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Published on: December 15, 2014

Differentiation Between Benign and Metastatic Breast Lymph Nodes Using Apparent Diffusion Coefficients.

Reza Fardanesh¹, Sunitha B Thakur^1,2, Varadan Sevilimedu³

¹Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

Frontiers in Oncology

|March 14, 2022

Summary

This summary is machine-generated.

This study determined apparent diffusion coefficient (ADC) values for benign versus malignant axillary lymph nodes. Mean ADC is the most effective parameter for differentiation, with an optimal threshold of 1.004×10⁻³ mm²/s.

Keywords:

MRI apparent diffusion coefficient breast cancer diffusion-weighted imaging lymph nodes prognostic factors

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Area of Science:

Radiology
Oncology
Medical Imaging

Background:

Axillary lymph node status is critical in breast cancer staging.
Accurate differentiation between benign and malignant lymph nodes is essential for treatment planning.

Purpose of the Study:

To establish apparent diffusion coefficient (ADC) value ranges for benign and malignant axillary lymph nodes.
To determine optimal ADC thresholds for differentiating benign from malignant axillary lymph nodes using minimum, maximum, and mean ADC values.

Main Methods:

Retrospective analysis of breast MRI data from 217 patients (January 2017-December 2020).
Two-year follow-up imaging or histopathology used as the reference standard for lymph node status.
Statistical analysis including Wilcoxon rank sum test and Youden's Index to determine AUC and optimal thresholds.

Main Results:

Significant differences in all ADC parameters (p<0.001) between benign and malignant axillary lymph nodes.
Mean ADC showed the least overlap, indicating it as the most useful parameter.
An optimal mean ADC threshold of 1.004×10⁻³ mm²/s achieved 75% accuracy, 71% sensitivity, and 79% specificity.

Conclusions:

Mean ADC is a valuable parameter for differentiating benign from malignant axillary lymph nodes.
The established mean ADC threshold differs from the European Society of Breast Imaging (EUSOBI) threshold for breast tumors.
The EUSOBI threshold should not be directly applied to axillary lymph node evaluation.