Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Erythrocyte Count, Anemia, and the Human Natural Lifespan Limit: Evidence from the Long Life Family Study.

bioRxiv : the preprint server for biology·2026

Same author

A Resampling-Based Framework for Network Structure Learning in High-Dimensional Data.

ArXiv·2026

Same author

Genetic associations with longevity in a Calabrian cohort: an exploratory genome-wide study.

GeroScience·2026

Same author

Psychometric modeling of Boston process approach data for dementia prediction in the Framingham Heart Study.

Journal of the International Neuropsychological Society : JINS·2026

Same author

Metabolomic signatures of extreme old age: findings from the New England Centenarian Study.

GeroScience·2026

Same author

Identification of novel plasma proteomic biomarkers of Dupuytren disease.

PloS one·2026

Same journal

Variable Aβ tracer uptake in hyperostosis frontalis interna: implications for brain Aβ PET/CT interpretation.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026

Same journal

Deep contrastive learning framework identifies cell-type-specific drug targets in Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026

Same journal

Anti-amyloid therapy eligibility in a longitudinal brain-donor cohort with <i>post mortem</i> confirmation.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026

Same journal

Performing multiple biomarker tests delays initiation of amyloid-targeting treatments.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026

Same journal

Development of a picture-based tool for subjective deficits in cognition and ADLs.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026

Same journal

Polypharmacy is associated with lower progression from MCI to Alzheimer's disease, with sex-specific patterns across drug classes.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 30, 2025

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test

Published on: November 23, 2019

Digitally generated Trail Making Test data: Analysis using hidden Markov modeling.

Mengtian Du^1,2, Stacy L Andersen³, Stephanie Cosentino^4,5

¹Department of Biostatistics Boston University Boston Massachusetts USA.

Alzheimer'S & Dementia (Amsterdam, Netherlands)

|March 14, 2022

Summary

This summary is machine-generated.

Digital versions of the Trail Making Test (TMT) capture more than just cognitive function. New metrics reveal insights into graphomotor processing, gait speed, memory, and grip strength.

Keywords:

Bayesian hidden Markov models Trail Making Test aging cognitive function digital biomarker

More Related Videos

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Published on: February 25, 2013

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb

Published on: August 30, 2016

Related Experiment Videos

Last Updated: Sep 30, 2025

Traditional Trail Making Test Modified into Brand-new Assessment Tools: Digital and Walking Trail Making Test

Published on: November 23, 2019

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Trajectory Data Analyses for Pedestrian Space-time Activity Study

Published on: February 25, 2013

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb

Sit-to-stand-and-walk from 120% Knee Height: A Novel Approach to Assess Dynamic Postural Control Independent of Lead-limb

Published on: August 30, 2016

Area of Science:

Neuropsychology
Digital Health
Biometrics

Background:

The Trail Making Test (TMT) is a standard neuropsychological tool for assessing cognitive dysfunction.
Traditional TMT administration relies on manual completion, limiting data capture to completion time.
Digital recording offers potential for richer data extraction beyond simple timing.

Purpose of the Study:

To explore the utility of digitally recorded TMT versions for assessing cognitive and physical functions.
To develop novel metrics from digital TMT data using advanced statistical modeling.
To correlate these digital metrics with established cognitive and physical performance measures.

Main Methods:

Digitally recorded versions of TMT-A and TMT-B were analyzed.
Time-based metrics were derived from digital recordings.
Bayesian hidden Markov models were employed to extract additional performance metrics.
Regression analyses correlated digital metrics with cognitive and physical function scores.

Main Results:

Digital TMT metrics from both TMT-A and TMT-B correlated with graphomotor processing speed and gait speed.
Digital TMT-B metrics showed additional associations with episodic memory scores and grip strength.
These findings suggest digital TMT metrics provide nuanced information on cognitive and physical states.

Conclusions:

Digitally recorded TMT offers enhanced insights into cognitive and physical function compared to traditional methods.
Novel digital metrics can differentiate between cognitive and physical factors influencing TMT performance.
This approach holds promise for more comprehensive neuropsychological assessments.