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Cell Population Analyses During Skin Carcinogenesis
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Basaloid squamous cell carcinoma.

V Jai Santhosh Manikandan1, P Sai Krishna1, L S Makesh Raj1

  • 1Department of Oral and Maxillofacial Pathology, Tagore Dental College and Hospital, Chennai, Tamil Nadu, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|March 14, 2022
PubMed
Summary
This summary is machine-generated.

Basaloid squamous cell carcinoma (BSCC) is a rare, aggressive cancer often found in the upper aerodigestive tract. This case highlights its unique biphasic histology and the use of tumor markers for accurate diagnosis.

Keywords:
Basaloid squamous cell carcinomaBerEp4epithelial membrane antigenoral cavityoropharynxp53squamous cell carcinoma

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma.
  • It presents with aggressive clinical behavior and distinct histopathological features, often in the upper aerodigestive tract.

Purpose of the Study:

  • To report a case of BSCC involving the lateral border of the tongue in a 48-year-old female.
  • To illustrate the histological and immunohistochemical characteristics of BSCC.
  • To emphasize the role of tumor markers in differentiating BSCC from mimics.

Main Methods:

  • Histopathological examination of the tumor.
  • Immunohistochemical analysis using tumor markers such as BerEp4, epithelial membrane antigen (EMA), and p53.
  • Clinical case presentation.

Main Results:

  • The tumor exhibited a biphasic pattern with both basaloid and squamous cell components.
  • Immunohistochemistry confirmed the diagnosis by demonstrating specific marker expressions.
  • The case involved the lateral border of the tongue.

Conclusions:

  • BSCC is a distinct clinicopathological entity requiring accurate diagnosis.
  • Immunohistochemistry is crucial for differentiating BSCC from histologically similar tumors.
  • This case underscores the importance of recognizing BSCC in the differential diagnosis of tongue and upper aerodigestive tract lesions.