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Updated: Jul 20, 2026
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
Published on: February 16, 2016
Evaluation of Level of TNF-α among Obese Patients with and without Chronic Periodontitis
Kamal Hameed Fathima1, Venkateshwaran Rajendran2, Prasanna Sekhar3
1Associate Professor, Department of Dentistry, Srimuthukumaran Medical College and Research Institute, Mangadu, Chennai, Tamil Nadu, India.
Aim:
The purpose of this case-control study was to evaluate the role of TNF-α in gingival crevicular fluid among obese women with chronic periodontitis.
Materials And Methods:
A total of 60 subjects were randomly selected for the study. The study population was further divided into three groups (Group 1, Obese women without periodontitis; Group 2, Non-obese women without periodontitis; Group 3, Obese with chronic periodontitis). Gingival crevicular fluid samples were taken for assessment based on clinical parameters like probing depth, bleeding on probing, and BMI.
Results:
There was significant increase in the level of TNF-α in gingival crevicular fluid from obese patients with chronic periodontitis and a positive correlation was found between TNF-α levels and values of the plaque index, OHI -I and BMI.
Conclusion:
Based on these results, it can be concluded that GCF level of TNF-α was significantly higher in obese patients with and without chronic periodontitis, and highest in obese patients with chronic periodontitis group.
