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Studying the Effects of Cold Plasma Phosphorus Using Physiological and Digital Image Processing Techniques.
Malik Bader Alazzam1, Walid Theib Mohammad2, Mohammad Bani Younis2
1Faculty of Computer Science and Informatics, Amman Arab University, Jordan.
Computational and Mathematical Methods in Medicine
|March 14, 2022
Summary
Cold plasma treatment shows significant positive effects on osteoporosis-infected rabbit bone tissue. This innovative therapy improved key bone health indicators, offering a promising new treatment approach.
Area of Science:
- Biomedical Engineering
- Materials Science
- Orthopedics
Background:
- Osteoporosis is a debilitating bone disease characterized by decreased bone density and increased fracture risk.
- Current treatments for osteoporosis have limitations and side effects.
- There is a need for novel therapeutic strategies to regenerate bone tissue affected by osteoporosis.
Purpose of the Study:
- To investigate the efficacy of cold plasma therapy in treating rabbit bone tissue infected with osteoporosis.
- To evaluate the impact of cold plasma on bone cell histopathology and biochemical markers.
- To assess the potential of image processing techniques in quantifying treatment outcomes.
Main Methods:
- Rabbit bone tissue models of osteoporosis were established and divided into control, infected, and cold plasma-treated groups.
- Cold plasma exposure was administered for five minutes at a microwave plasma voltage of 175 V and gas flow of 2.
- Histopathological analysis of bone cells and biochemical assays for calcium, vitamin D, osteocalcin, and alkaline phosphatase (ALP) were performed.
- Image processing using a second-order gray level matrix was employed to analyze textural features of bone tissue.
Main Results:
- Cold plasma treatment demonstrated a significant positive impact on calcium and vitamin D levels in infected bone tissue.
- Osteocalcin and alkaline phosphatase (ALP) levels showed a favorable response to cold plasma exposure.
- Histopathological examination revealed reduced bone destruction and improved cellular structure post-treatment.
- Image processing analysis corroborated the biological findings, showing distinct textural changes corresponding to treatment efficacy.
Conclusions:
- Cold plasma therapy is a promising approach for treating osteoporosis-affected bone tissue.
- The study provides strong evidence for cold plasma's ability to modulate key bone metabolism markers.
- Integrated histopathological and image analysis offers a robust method for evaluating therapeutic outcomes in bone regeneration.
