ABO BLOOD GROUP GENOTYPES IN WOMEN WITH BREAST CANCER

Area of Science:

• Genetics and Oncology
• Cancer Risk Factors
• Blood Group Phenotypes

Background:

• The ABO blood group has been implicated as a risk factor in various cancers.
• The specific association between ABO blood types and breast cancer risk remains unclear.
• Tumor markers such as estrogen receptor (ER), progesterone receptor (PR), and HER2 status are crucial for breast cancer classification.

Purpose of the Study:

• To investigate the potential correlation between ABO blood group genotypes and phenotypes and the occurrence of breast cancer.
• To examine the relationship between ABO blood group genotypes and tumor grade markers (ER, PR, HER2 status) in breast cancer patients.

Main Methods:

• A case-control study involving 59 invasive breast cancer patients and 80 healthy controls.
• Genomic DNA extraction using the QIAampDNA Blood Mini Kit.
• ABO blood group genotyping performed via in-house polymerase chain reaction with sequence-specific primers (PCR-SSP).

Main Results:

• No statistically significant differences were observed in the distribution of ABO blood group genotypes or phenotypes between breast cancer patients and the control group (p>0.05).
• There was no significant correlation found between ABO genotypes/phenotypes and the occurrence of breast cancer.
• No statistical significance was found regarding the association of ABO genotypes (O1A1 vs. non-O1A1) with tumor grade or the status of ER, PR, and HER2/neu markers.

Conclusions:

• The study concludes that ABO blood type genotypes and phenotypes are not correlated with breast cancer occurrence in the studied population.
• ABO blood groups do not appear to influence breast cancer risk or the expression of key tumor markers (ER, PR, HER2).